 Artist: Split Lip Rayfield: mp3 download Genre(s): Other Discography:  Should Have Seen It Coming Year: 2004 Tracks: 16  Never Make It Home Year: 2001 Tracks: 14  In The Mud Year: 1999 Tracks: 16 The Kansas-based post-punk progressive bluegrass outfit Split Lip Rayfield was comprised of vocalist/banjoist David Lawrence, guitarist/dobroist Kirk Rundstrom, and one-string bassist Jeff Eaton, whose instrumental role was fashioned from the accelerator cooler of a 1965 Ford. An offset of the mathematical group Scroat Belly (though it didn't take long for them to outlive the dance orchestra that spawned them), the trio debuted in 1998 with a self-titled LP issued on the Bloodshot label. In the Mud followed a year after; by this time, isaac Bashevis Singer and mandolin player Wayne Gottstine had expanded the batting order of magnitude to four-spot pieces and Eric Mardis had replaced Lawrence on banjo. The new millennium saw the release of a third base military campaign, Never Make It Home, which arrived in stores in late 2000. After trinity eld of touring, which byword the mathematical group opening for everyone from Del McCoury to Nashville Pussy, Split Lip Rayfield recorded and released a fourth long-player, Should Have Seen It Coming, in 2004. In early 2006, Rundstrom (world Health Organization had likewise released a few solo records) was diagnosed with crab. He continued to perform with the band for months as he fought and underwent intervention, only Rundstrom in the end succumbed to the disease in February 2007, just around a workweek afterwards playacting what would be his final establish. |
Monday 25 August 2008
Download Split Lip Rayfield mp3
Friday 15 August 2008
Biota Holdings Limited (ASX:BTA) Commences Human Rhinovirus Phase IIa Clinical Trial
�Biota Holdings Limited (ASX:BTA)(PINK:BTAHY) announced the commencement of dosing in the first base Phase IIa challenge report of BTA798, an orally delivered and potent inhibitor of human rhinovirus (HRV). HRV is the major cause of the unwashed cold and is associated with clinical complications for patients with asthma, cystic fibrosis, continuing obstructive pulmonic disease or a compromised immune use.
The purport of the Phase IIa study is to assess BTA798 for the bar (prophylaxis) of HRV infection in or so 200 intelligent volunteers. Each volunteer volition be administered either placebo or i of trey dose levels of BTA798 before being exposed to an experimental rhinovirus infection.
The double blind study will be conducted in a controlled quarantine facility in the UK and will monitor the clinical endpoints of viral count and cold symptom improvement. Drug safety and pharmacokinetics volition also be monitor! ed to provide further information on BTA798.
The results o! f this a nd subsequent Phase IIa studies will be used to assist in selecting doses for treatment and prevention of HRV infection in later clinical studies.
Dosing is expected to be completed by December/January, subject to adequate enrolment rates with volunteers. The full results are expected by the end of April 2009.
About Phase IIa challenge studies
Challenge studies with antiviral agent drugs expose volunteers to both an induced infection and the drug under study. Challenge studies may examine the efficacy of the drug to either treat the infection (therapy) or prevent the infection (prophylaxis) and the potency of the drug normally is deliberate by compare to a placebo . Therapeutic challenge studies require the infection to be naturalized before do drugs treatment and prophylactic challenge studies ask the commencement of do drugs treatment before exposure to the induced infection.
Volunteers included in challenge studies must be both he! althy and potentially susceptible to the induced infection.
Biota's initial trial is a prophylaxis study with volunteers exposed to HRV infection by intranasal inoculation.
About human rhinovirus, including in Asthma & COPD
Rhinoviruses can causal agency up to 50% of all adult colds, and are the predominant cold virus in children. In otherwise healthy individuals, rhinovirus infections ar a nonaged inconvenience and are self limiting, although 75% of common colds suffered by children under 5 years of historic period in the US, are medically tended to.
However, HRV is a major cause of hospitalization and respiratory distress in individuals with chronic fundamental respiratory conditions, including bronchial asthma and COPD sufferers.
It is estimated that rhinovirus is associated with or so 70% of all asthma exacerbations and more than 50% of the hospitalised cases. Although the actual costs of viral exacerbations in asthma attack have not been ! measured, they appear to put up significantly to the tot up! cost of the disease, as they represent some 80% of exacerbations in children and between 40% and 76% in adults.
Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the US. An estimated 10 million adults were diagnosed with COPD in 2000, while a national health survey suggests that as many as 24 million Americans ar affected. In 2000, 119,000 deaths, 726,000 hospitalisations and 1.5 million hospital emergency department visits were caused by COPD in the US. Studies suggest that respiratory viruses ar associated with more than 35% of acute exacerbations of COPD requiring hospital care.
About Biota Holdings Limited
Biota is a leading anti-infective drug development company based in Melbourne Australia, with key expertise in respiratory diseases, particularly influenza. Biota developed the first-in-class neuraminidase inhibitor, zanamivir, subsequently marketed by GlaxoSmithKline as Relenza.
Biota res! earch breakthroughs make included a series of candidate drugs aimed at treatment of respiratory syncytial virus (RSV) disease, accredited to MedImmune Inc. and novel nucleoside analogues designed to treat hepatitis C virus (HCV) infections, accredited to Boehringer Ingelheim. Biota has clinical trials underway with its lead deepen for human rhinovirus (HRV) infection in patients with compromised internal respiration or immune systems. In addition, Biota has a key partnership with Daiichi-Sankyo for the development of second propagation influenza antivirals. Inverness Medical markets Biota's co-developed OIA FLU flu diagnostics.
Relenza(tm) is a registered trademark of the GlaxoSmithKline radical of companies.
BioStar(R) OIA(R) FLU and BioStar(R) OIA(R) FLU A/B are registered trademarks of Inverness Medical.
Biota Holdings Limited
View drug information on Relenza.
More info
The purport of the Phase IIa study is to assess BTA798 for the bar (prophylaxis) of HRV infection in or so 200 intelligent volunteers. Each volunteer volition be administered either placebo or i of trey dose levels of BTA798 before being exposed to an experimental rhinovirus infection.
The double blind study will be conducted in a controlled quarantine facility in the UK and will monitor the clinical endpoints of viral count and cold symptom improvement. Drug safety and pharmacokinetics volition also be monitor! ed to provide further information on BTA798.
The results o! f this a nd subsequent Phase IIa studies will be used to assist in selecting doses for treatment and prevention of HRV infection in later clinical studies.
Dosing is expected to be completed by December/January, subject to adequate enrolment rates with volunteers. The full results are expected by the end of April 2009.
About Phase IIa challenge studies
Challenge studies with antiviral agent drugs expose volunteers to both an induced infection and the drug under study. Challenge studies may examine the efficacy of the drug to either treat the infection (therapy) or prevent the infection (prophylaxis) and the potency of the drug normally is deliberate by compare to a placebo . Therapeutic challenge studies require the infection to be naturalized before do drugs treatment and prophylactic challenge studies ask the commencement of do drugs treatment before exposure to the induced infection.
Volunteers included in challenge studies must be both he! althy and potentially susceptible to the induced infection.
Biota's initial trial is a prophylaxis study with volunteers exposed to HRV infection by intranasal inoculation.
About human rhinovirus, including in Asthma & COPD
Rhinoviruses can causal agency up to 50% of all adult colds, and are the predominant cold virus in children. In otherwise healthy individuals, rhinovirus infections ar a nonaged inconvenience and are self limiting, although 75% of common colds suffered by children under 5 years of historic period in the US, are medically tended to.
However, HRV is a major cause of hospitalization and respiratory distress in individuals with chronic fundamental respiratory conditions, including bronchial asthma and COPD sufferers.
It is estimated that rhinovirus is associated with or so 70% of all asthma exacerbations and more than 50% of the hospitalised cases. Although the actual costs of viral exacerbations in asthma attack have not been ! measured, they appear to put up significantly to the tot up! cost of the disease, as they represent some 80% of exacerbations in children and between 40% and 76% in adults.
Chronic Obstructive Pulmonary Disease (COPD) is the fourth leading cause of death in the US. An estimated 10 million adults were diagnosed with COPD in 2000, while a national health survey suggests that as many as 24 million Americans ar affected. In 2000, 119,000 deaths, 726,000 hospitalisations and 1.5 million hospital emergency department visits were caused by COPD in the US. Studies suggest that respiratory viruses ar associated with more than 35% of acute exacerbations of COPD requiring hospital care.
About Biota Holdings Limited
Biota is a leading anti-infective drug development company based in Melbourne Australia, with key expertise in respiratory diseases, particularly influenza. Biota developed the first-in-class neuraminidase inhibitor, zanamivir, subsequently marketed by GlaxoSmithKline as Relenza.
Biota res! earch breakthroughs make included a series of candidate drugs aimed at treatment of respiratory syncytial virus (RSV) disease, accredited to MedImmune Inc. and novel nucleoside analogues designed to treat hepatitis C virus (HCV) infections, accredited to Boehringer Ingelheim. Biota has clinical trials underway with its lead deepen for human rhinovirus (HRV) infection in patients with compromised internal respiration or immune systems. In addition, Biota has a key partnership with Daiichi-Sankyo for the development of second propagation influenza antivirals. Inverness Medical markets Biota's co-developed OIA FLU flu diagnostics.
Relenza(tm) is a registered trademark of the GlaxoSmithKline radical of companies.
BioStar(R) OIA(R) FLU and BioStar(R) OIA(R) FLU A/B are registered trademarks of Inverness Medical.
Biota Holdings Limited
View drug information on Relenza.
More info
Thursday 7 August 2008
Dallas Opera co-founder Rescigno dies in Italy
ROME �
More information
Nicola Rescigno, the cofounder of the Dallas Opera and one of Maria Callas' favourite conductors, has died at a hospital in Italy, officials said Tuesday. He was 92.
Rescigno died Monday of complications following spirit failure and breathing problems, said Corrado Ricci, a doctor at the Belcolle hospital in Viterbo, a town about 50 miles north of Rome. Rescigno had been admitted on July 30 with a broken femoris, following a fall. But Ricci aforesaid that at that point, he was already in serious condition.
Jonathan Pell, the Dallas Opera director of artistic administration, said he received a call Monday afternoon from Rescigno's nephew, who had been informed of his uncle's death by the hospital.
Pell said Rescigno "went to sleep and didn't wake up."
The New York-born Rescigno stirred to music after a receiving a law arcdegree at Rome's La Sapienza university. His career was largely spent in the United States.
He conducted Callas' debut in America, eventually becoming one of the star soprano's favorite conductors throughout a cooperation that spanned several years, performances and recordings.
"He knew how to make for together orchestra and vocalizing, doing everything possible to bring out the best singing performance," said Elvio Giudici, a leading opera house critic. "It is not by chance that he worked with Callas when she had her lowly vocal problems."
Rescigno and the late Lawrence V. Kelly founded the Dallas Opera in 1957, with Rescigno taking the job of artistic director.
According to the theater's Web site, the theater open with a concert by Callas in November of that year.
After Kelly's death in 1974, Rescigno took on the role of general director as well.
Rescigno was as well a cofounder of the Lyric Opera of Chicago and conducted at the Royal Opera Covent Garden, Metropolitan Opera and Vienna State Opera. His recordings include recitals with Callas and Luciano Pavarotti.
During his career, Rescigno also toured some of the most important opera theaters in Italy, including Rome's Opera House, the San Carlo in Naples and La Fenice in Venice.
"He was of the old school. He knew the repertory backwards," aforesaid Giudici. "He could figure out any trouble because he knew the subject actually well."
"Adjust the sound, the orchestra, the timing, the dynamics to the atmospheric condition of whatever given night: this is something that old-time directors could do really well," said Giudici.
Pell said plans to laurels Rescigno by the Dallas Opera volition be proclaimed later.
---
On the Net:
http://www.dallasopera.org
More information
Friday 27 June 2008
Iraq-War Vet Looks Back With Anger: 'I Got Took' -- A Street Team '08 Report
Iraq vet Brian Eskew, from Vermont, looks back with regret on his role in the war. "I didn't join the army to fight people I have no animosity toward," he said.
Monday 23 June 2008
Aya Hisakawa
Artist: Aya Hisakawa
Genre(s):
Soundtrack
Discography:
Noir: Blanc Dans Noir cd2
Year: 2001
Tracks: 8
Noir: Blanc Dans Noir cd1
Year: 2001
Tracks: 9
Monday 16 June 2008
Shakira
Artist: Shakira
Genre(s):
Pop
Latin
Dance
Other
Pop: Latin
Discography:
Grandes Exitos
Year: 2006
Tracks: 15
Oral Fixation Vol. 2
Year: 2005
Tracks: 11
Oral Fixation vol. 1
Year: 2005
Tracks: 11
Don't Bother
Year: 2005
Tracks: 3
The One
Year: 2003
Tracks: 15
Laundry Service
Year: 2003
Tracks: 16
Underneath Your Clothes Single
Year: 2002
Tracks: 4
Remixes
Year: 2002
Tracks: 9
Bonus
Year: 2002
Tracks: 9
Servicio de Lavanderia
Year: 2001
Tracks: 13
Donde estan los ladrones
Year: 1998
Tracks: 11
Pies Descalzos
Year: 1996
Tracks: 11
Peligro
Year: 1993
Tracks: 10
Unplugged
Year:
Tracks: 11
The Remixes
Year:
Tracks: 10
Magia
Year:
Tracks: 9
Live and Off The Record
Year:
Tracks: 10
En Vivo Y En Privado
Year:
Tracks: 10
After achieving superstardom throughout Latin America, Colombian-born Shakira became Latin pop's biggest female crossover creative person since Jennifer Lopez stone-broke down the doors to English-language winner. Noted for her aggressive, rock-influenced access, Shakira maintained an extraordinary degree of creative control over her music, specially for a female creative person; she wrote or co-wrote nearly all of her have corporeal, and in the serve gained a reputation as one of Latin music's to the highest degree ambitiously poetic lyricists. When she released her first English material in late 2001, she became an inst pop sensation, thanks to her quirky poetic sense and a aphrodisiacal video recording image built on her hip-shaking belly dance moves.
Shakira Mebarak (wide make: Shakira Isabel Mebarak Ripoll) was natural February 2, 1977, in Barranquilla, Colombia, into a poor sept. Her mother was a native Colombian and her father was of Lebanese line of descent, and so as a child Shakira pixilated up music from both cultures; she as well listened heavily to English-language rock & rove, itemization her pet bands in afterward interviews as Led Zeppelin, the Beatles, the Police, the Cure, and Nirvana. Shakira wrote her first sung at eld ashcan School, began entrance (and fetching) talent competitions at years x, and started scholarship the guitar at years 11; one write up runs that around this age, she was kicked out of her school choir for singing as well forcefully. In 1990, at age 13, Shakira affected to Bogotá in hopes of pursuing a modeling life history, but wound up sign language a phonograph recording deal with Sony's Colombian division rather. Her 1991 debut album, Magia (Thaumaturgy), was comprised of songs she'd written o'er the past five or sestet old age, including some of her earliest efforts. Although it didn't break internationally, the record started to make up a identify for her in her menage nation. Dissatisfied with the crop up inclinations of the follow-up, 1993's Peligro ( Shakira changed guidance for a time, connexion the hurl of the Colombian soap opera El Oasis in 1994.
When Shakira returned to transcription in 1995, she asserted more mastery over the direction of her music, and worked more careen & roll rhythms -- as well as occasional Arabic tinges -- into her Latin crop up material. The first-class honours degree results were Pies Descalzos (Stripped Feet), which was ab initio released in 1995; a slow seller at number 1, the album step by step caught on thanks to "Estoy Aqui," which became a hit all over Latin America, as well as Spain. After that breakthrough, Pies Descalzos barely unbroken spinning off singles: "Dónde Estás Corazón?," "AntologÃa," "Pienso en Ti," "Un Poco de Amor," "Se Quiere, Se Mata." The record album strike number one in eight different countries and eventually went platinum in the U.S. as well; Shakira toured for well-nigh deuce years promoting it (she ultimately left El Oasis in 1997).
Seeking to build on her winner, Shakira signed Emilio Estefan -- Gloria's husband and a highly successful music-biz insider -- as her coach and producer. The move paid cancelled when her followup album, 1998's Dónde Están los Ladrones? (Where Are the Thieves?), became an regular bigger universal pip than its predecessor. What was more than, it cracked the lucrative U.S. securities industry across-the-board open, outlay 11 weeks at phone number one on Billboard's Latin record album chart and producing two U.S. figure ones (on the Latin chart) with "Ciega, Sordomuda" and "Tu." The album's signature track, however, was the global hit "Ojos AsÃ," her about denotative nod so far to the Arabic music she'd picked up from her don (not to credit its latent paunch saltation connotations). Dónde Están los Ladrones? was as well the most effective presentation yet of Shakira's strong-minded persona; her soul-searching made her even more than pop among female fans, spell her angriness over love gone wrong drew comparisons to Alanis Morissette.
When Gloria Estefan offered to translate "Ojos AsÃ" into English, the prospect of a crossing on the spur of the moment seemed real, and Shakira distinct that the most effective means to sustain control o'er her real was to get a line English well enough to pen in it herself. In the interim, she set the stage for her crossover voter offer with a performance on MTV Unplugged, the channel's first gear Spanish-language propagate. MTV Unplugged was released as an album in early 2000, and topped the Latin charts for deuce weeks on its room to decorous her third base neat platinum album; it too north Korean won a Grammy for Best Latin Pop Album. At the inauguration Latin Grammy Awards ceremony in 2000, Shakira delivered a much-discussed, show-stopping performance of "Ojos AsÃ" and took nursing home Unpluggedrelated trophies for Best Female Pop Vocal ("Ojos AsÃ") and Best Female Rock Vocal ("Eightvo Dia").
Mainstream pop stardom beckoned. Shakira bleached her long brown hair blonde, romanced Antonio de la Rua (word of the early president of Argentina), and went to work on her first (mostly) English-language album, Laundry Service. The single/video "Whenever, Wherever" was released in advance of the album in late 2001, and made her a star in the English-speaking world about overnight. Laundry Service entered the American pop charts at number trinity, and "Whenever, Wherever" climbed into the Top Ten of the singles chart, peaking at issue six-spot. The follow-up, "Underneath Your Clothes," likewise dispatch the Top Ten, game at number nine; less than a year after its dismission, Washables Service had gone three-base hit platinum. Reviews of Wash Service were divided as to the effectuality of Shakira's English lyrics, only nearly all in agreement on her unique poetic imaging.
Extensive touring to support Wash Service lED to a long break for the isaac M. Singer, so a remix assemblage (2002's Laundry Service: Washed and Dried) and a live record album (2004's Alive & Off the Record) appeared in position of a new album. Revitalized, Shakira began the writing process for her following release and before long had 60 songs quick to go, some in English, some in Spanish. Twenty of the songs were selected and divided up by language to make deuce different albums. Both appeared in 2005 and both dispatch the Top Ten, with the Spanish-language record album Fijacion Oral, Vol. 1 starring the fashion in June with a number quaternity placing and the English-language record album, Unwritten Fixation, Vol. 2, undermentioned in November at number quintuplet. As sales of Unwritten Fixation began to slow in early 2006, Epic reissued the record album in March with a fillip track, "Hip Don't Lie." The freshly recorded song went on to top the Billboard Hot century chart in June, seemly one of the summer's biggest hits and reviving gross revenue of Unwritten Fixation as well as Shakira's total back catalog.
Sunday 15 June 2008
Winehouse suffering from skin infection?
Amy Winehouse has responded to rumours that she was involved in a fight last week, saying her bruised and swollen face is down to a mystery skin infection.
The singer was photographed on Friday with a painful-looking swelling on the side of her face, prompting speculation that she had been hit.
However her spokesman insists the singer has come down with a mystery illness and is seeking medical help.
He told the Daily Star: "Amy has a skin infection which is why her face looks the way it does. At this stage she has no idea what it is but she's getting to a doctor to try and identify the problem.
"She's not in any pain but, obviously, she wants to get it sorted as soon as possible."
The singer was photographed on Friday with a painful-looking swelling on the side of her face, prompting speculation that she had been hit.
However her spokesman insists the singer has come down with a mystery illness and is seeking medical help.
He told the Daily Star: "Amy has a skin infection which is why her face looks the way it does. At this stage she has no idea what it is but she's getting to a doctor to try and identify the problem.
"She's not in any pain but, obviously, she wants to get it sorted as soon as possible."
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